CURRENT VACCINES

Tetanus toxoid (TT)Clostridium tetani culture is grown in a special medium and detoxified with formaldehyde. The detoxified material is then purified, followed by sterile filtration, and the toxoid is adsorbed to Aluminium Phosphate (AlPO 4 ) . The adsorbed toxoid is diluted with physiological saline solution and thiomersal is added to a final concentration.

Diphtheria Tetanus (DT) The Diphtheria and Tetanus toxoids are prepared from the toxins of cultures of Corynebacterium diphtheriae and Clostridium tetani by formalin inactivation using established technology. The adsorbed toxoid is diluted with physiological saline solution and thiomersal is added to a final concentration.

Diphtheria Tetanus Whole cell Pertussis (DTwP)The Diphtheria and Tetanus toxoids are prepared from the toxins of cultures of Corynebacterium diphtheriae and Clostridium tetani by formalin inactivation using established technology. The Pw component is obtained by heat inactivation of phase I culture of Bordetella pertussis bacteria. The content is diluted with physiological saline solution and thimerosal is added to a final concentration

Anti-Tetanus Serum - Equine (ATS)This vaccine is prepared from the blood of normal healthy horses by injecting them with tetanus toxoid. It is used for the treatment or immediate, temporary prevention of tetanus (lockjaw) caused by Clostridium tetani toxin.

Anti-Snake Venom (ASVS)The anti snake venom is a preparation from the equine plasma of hyperimmunised horses against four common poisonous snakes of India. 1) Cobra (Najanaja) 2) Common Krait (Bungarus Caeruleus), 3) Russels viper (Vipera russeli) and 4) Saw scaled viper (Echis carinatus). Plasma obtained from the hyperimmunized horses is enzyme refined, purified and concentrated.

Hepatitis-B VaccineThe surface antigen of the HBV (HBsAg) is produced by culture of genetically-engineered yeast cells (Pichia Pastoris) which carry the gene coding for the major surface antigen of the HBV. This HBsAg expressed in yeast cells is purified by several physico-chemical steps. The HBsAg assembles spontaneously, in the absence of chemical treatment, into spherical particles of 20 nm in average diameter containing non-glycosylated HBsAg polypeptide and a lipid matrix consisting mainly of phospholipids. Extensive tests have demonstrated that these particles display the characteristic properties of the natural HBsAg.